Microbial catalyzed ceramic materials can promote bone tissue regeneration
Science and Technology Daily News (Reporter Wang Chun) The reporter learned from the Shanghai Institute of Ceramics, Chinese Academy of Sciences on November 22 that the research team of Wu Chengtie proposed the idea of microbial catalysis of active minerals to induce bone formation, and the use of microbial catalysis to construct Micro-nano structure on the surface of bioceramic scaffold for bone tissue regeneration.
Relevant research results were published in the latest issue of the international academic journal "Advanced Materials" under the title "Microbial Catalytic Bioceramics for Bone Regeneration".
Inspired by the phenomenon of microbial mineralization in nature, Wu Chengtie’s team used microbial catalysis to grow biologically active nano-calcium carbonate minerals on the surface of traditional ceramic materials (silicate), combining traditional ceramic materials with microbial-based active materials for use Bone tissue regeneration.
Bone is a complex biomineralized tissue composed of organic (cells, proteins) and inorganic (hydroxyapatite, calcium carbonate) materials at the micro-nano scale.
Ideal biomaterials need to have excellent osteoconductivity and osteoinductivity, and can efficiently promote the formation of new bone.
More and more studies have shown that the micro-nano morphology and chemical characteristics of the surface of biomaterials can effectively regulate the osteogenic activity of cells.
However, the surface modification of traditional 3D printing ceramic scaffolds is mainly based on chemical methods such as hydrothermal method and organic template method. This non-biologically controlled mineralization process is not conducive to the control of crystal size and crystallinity, which limits its biology. Efficient play of the effect.
The research team used the metabolism of urease-producing bacteria to induce a uniform biomineralization layer on the surface of the ceramic material.
The nano calcium carbonate minerals constructed by microorganisms on the surface of ceramic materials obviously inhibit the rapid degradation of calcium silicate ceramics, and have a better promotion effect on the adhesion, spreading, proliferation, migration and differentiation of bone marrow mesenchymal stem cells. .
In animal experiments of subcutaneous implantation and repair of large bone defects, the biomaterials catalyzed by microorganisms have good biocompatibility and show significant activity in promoting bone tissue regeneration.
In addition to being used for bone tissue regeneration, this strategy of combining microorganisms with tissue engineering also provides new ideas for the preparation of biomedical materials.