La Roja is guaranteed to finish in the top two of the group while Greece are now eliminated.
The victory, combined with Sweden's defeat in Georgia earlier in the evening (2-0), allows Spain to lead Group B with 16 points, one more than Zlatan Ibrahimovic's teammates.
Swedish striker Zlatan Ibrahimovic, during the match against Georgia, counting for the qualifiers of the 2022 World Cup in Qatar, on November 11 in Batumi Vano SHLAMOV AFP
The Spaniards and Swedes will meet in Seville on Sunday for the final day of the qualifiers, in which a draw will suffice for Luis Enrique's men to validate their ticket to Qatar.
After a rhythmic first quarter of an hour but without any real opportunity, La Roja gradually took control of the match.
Spurred on by a very mobile Gavi and available to his partners, the Spaniards monopolized the ball, stifling a limited Greek selection.
The Greeks, deprived of their captain and playing master Anastasios Bakasetas, nevertheless believed to open the scoring in the 20th minute when Giorgos Masouras won his face-to-face with Unai Simon, but the Greek striker was signaled in position of out -Game.
Spain logically opened the scoring in the 25th minute after several hot situations in the Hellenic area.
Pablo Sarabia converted a penalty after Dimitris Giannoulis fouled Inigo Martinez following a corner kick, confirmed by VAR.
The former Parisian took Odisseas Vlachodimos on the wrong foot to score his fifth goal in the selection.
Spanish striker Pablo Sarabia scores on a penalty, the only goal to win against Greece, during the 2022 World Cup qualifiers in Qatar, November 11, 2021 in Athens ARIS MESSINIS AFP
Alvaro Morata could have made the break in the 35th but the Spanish striker lost his duel against the Greek goalkeeper.
Largely superior technically and collectively, Luis Enrique's men mastered the second half and could have increased their lead if the entrants Rodrigo or Dani Olmo had been more precise in the last movement.
© 2021 AFP