The structure of intestinal flora affects the weight loss effect of low-carbon diet

  Science and Technology Daily News (Reporter Long Yuemei, Correspondent Li Chengbin) On September 21, the reporter was informed that the team of Xie Liwei, a researcher at the State Key Laboratory of Applied Microbiology in South China and the Institute of Microbiology, Guangdong Academy of Sciences, joined forces with Chen Hong and Sun, professors of the Department of Endocrinology and Metabolism, Zhujiang Hospital of Southern Medical University. Jia's research has discovered the determinants of the weight loss effect of a low-carbohydrate diet (LCD).

The research paper was published in the journal Microbial Spectroscopy.

  Globally, the number of overweight and obese people is increasing rapidly. Obesity and its complications not only seriously affect the quality of life of individuals, but also bring heavy economic burdens to society and families.

LCD is a dietary intervention model for weight loss treatment. However, in different studies, the weight loss effects of LCD intervention are quite different. There is currently no sufficient evidence to explain this heterogeneity.

  Through prospective, randomized controlled clinical studies, combined with high-throughput sequencing and bioinformatics big data analysis, researchers found that the structure of the intestinal flora is a determinant of the short-term LCD weight loss effect for overweight and obese people.

In addition, the research provides a new strategy and method for clinical medicine weight management and intervention by constructing an artificial neural network model based on the structure of the intestinal flora to predict the weight loss effect of LCD.