Combining the advantages of two traditional vaccines through virus-like particles
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Science and Technology Daily (Reporter Liu Xia) American scientists have developed a new type of virus-like particle vaccine for the new crown.
Tests conducted on experimental mice have shown that the new vaccine can induce a stronger immune response in experimental mice and is very effective against mutant strains of the new coronavirus.
Related papers were published in the latest issue of the journal "Public Science Library Pathogens", providing a new way for the global fight against the new coronavirus and its new mutant strains.
In this study, scientists combined the advantages of virus-based vaccines and protein-based vaccines, two traditional vaccines, to prepare a bacterial protein that can self-assemble into virus-like particles.
By displaying the protein of the new coronavirus on the surface of this virus-like particle, researchers have developed this new type of vaccine, which can be recognized by the immune system of mammals but is not infectious.
Research carried out on experimental mice found that compared to using only protein-based vaccines, the new vaccine induces a stronger immune response in animals, is very effective against mutant strains of the new coronavirus, and can effectively protect mice from the new coronavirus. Viral infection.
The research leader, Dr. Li Fang, a professor in the Department of Veterinary Medicine and Biomedicine at the University of Minnesota, said: “The global fight against the new coronavirus requires more effective and safe vaccines. Virus-like nanoparticle systems will be further developed to provide various new coronaviruses. Vaccines help humans and animals fight against the new coronavirus and its various mutant strains."