They were met by a large number of police officers who used both tear gas and rubber bullets to disperse the crowd.
In addition to the resignation of the Prime Minister, the protesters demanded reforms of the country's political system and a more effective vaccination program.
The first-mentioned demands are an echo of the youth-led protest movement that emerged last year and which gathered tens of thousands of participants at demonstrations in the capital.
The protest movement attracted particular attention as the participants also dared to demand reforms of the monarchy, which are protected by draconian majestic criminal laws.
An escalating pandemic and arrests of leading figures in the movement contributed to the protests subsiding around New Year.