China News Service, July 16th (Chen Jing and Yang Jing) The influence of anesthetics on patients' brain function and tumor recurrence and metastasis has been controversial for a long time.
The reporter learned on the 16th that Professor Shen Yuan, Director of the Department of Psychiatry, Shanghai Tenth People’s Hospital and Executive Deputy Director of the Institute of Anesthesia and Brain Function, Tongji University School of Medicine, and Professor Xie Zhongcong, Director of the Geriatric Anesthesia Laboratory, Harvard University Massachusetts General Hospital After two years of exploratory research, the team has confirmed from multiple levels that the commonly used intravenous anesthetic propofol may increase the risk of tumor invasion and metastasis.
Related papers have just been published online in the well-known academic journal "Advanced Science".
In previous cytotoxicological experiments, researchers observed that propofol, a widely used intravenous anesthetic in clinical practice, can significantly increase the adhesion of tumor cells to the vascular endothelium.
Propofol can make more tumor cells adhere to vascular endothelial cells.
Research schematic photo
According to reports, circulating tumor cells (CTCs) are considered to be the main factor in tumor metastasis and recurrence after surgery, and the adhesion of circulating tumor cells and vascular endothelial cells can promote tumor cells to break through blood vessels and invade into tissues.
What kind of interaction exists between anesthesia, tumors, and brain function?
With a series of questions, the researchers started a two-year exploration.
It is reported that the researchers took colon cancer cells as the main research object, and through modeling, simulated the process of contact between propofol and circulating tumor cells in blood vessels during the clinical perioperative period.
Experimental results in mice further indicate that propofol may increase the invasion and metastasis potential of colon cancer cells and cause distant lung metastasis.
The research team also proved the mechanism of the effect of propofol to promote tumor cell adhesion and extension through research.
Next, the researchers used the same in vitro pretreatment method to observe more tumor cells, including lung cancer, endometrial cancer cells, etc., and found that propofol can make more tumor cells adhere to vascular endothelial cells compared to the control group , And accompanied by a larger extension area and more adhesion spots formation.
Based on this, the researchers further locked the important target for the development of anti-cancer drugs, and also an important proto-oncogene-Src kinase that mediates cell adhesion.
It is reported that the discovery has very important clinical significance in the fields of anesthesiology, oncology and surgery.
It is understood that the Shenyuan team has continued to in-depth exploration in the fields of anesthesia, tumors and brain function in recent years, and initially discovered the mutual influence of anesthesia, AD and other diseases with the occurrence and development of tumors. In the future, experts will further clarify the interaction mechanism between the three in the research, hoping that the results of basic scientific research can be used in the clinic to improve the prognosis and clinical outcome of patients. (Finish)