What is the difference between the German-American Pfizer-BioNTech vaccine and the Chinese Sinovac vaccine?

Are there differences between their side effects?

Do they fit certain categories more than others?

The answers are in this report.

The Pfizer-Biontech vaccine, developed by the US company "Pfizer" and its German partner, "Biontech", works on "messenger RNA" or "mRNA" technology, a molecule that tells our cells what to make.

This vaccine is injected into the body, and it introduces this molecule that controls a mechanism for making a specific antigen for the "spike" Corona virus, which is a very distinctive tip that is present on its surface and allows it to adhere to human cells to penetrate them.

This spike will then be detected by the immune system, which will produce the antibodies, and these antibodies will remain for a certain period of time.

The Sinovac vaccine - CoronaVac - contains the Corona virus inactivated by various chemical processes in the laboratory.

The shell of this virus remains intact, and through injection, the immune system learns to recognize and defend itself against the virus.

It should be noted that Sinovac is the name of the Chinese company that developed the vaccine, and the name of the vaccine itself is Coronavac, but they are used to refer to the same meaning, which is the vaccine against Corona.

Are there differences between the Pfizer-Bionic and Sinovac vaccines in terms of side effects?

Do they fit certain categories more than others?

Turkish Professor Ismail Balik, Head of the Infectious Diseases Department at the Faculty of Medicine at Ankara University, said - in statements to Anadolu Agency - that their observations and experiences show that citizens can recommend the inactivated vaccine (Sinovac) over the mRNA vaccine (Pfizer-Biontek) if their bodies are more Prone to allergies, because the inactivated vaccine has milder side effects.

He added, "The mRNA vaccines cause a more severe immune response and their effect on stimulating the immune system is stronger than the inactive vaccines."

"Therefore, people whose immune response is weak, such as those suffering from obesity, kidney disease, diabetes, those receiving cancer treatment and others can prefer the Pfizer-Biontech RNA vaccine over the inactivated Sinovac vaccine," he said. However, it must be made clear that the inactivated vaccine is also effective. With these categories. "

Baliq indicated that the effect of the Pfizer-Bionic vaccine is stronger in the elderly, but that the chances of developing side effects are greater.

And he indicated that the side effects are clearer with the Pfizer-Biontech vaccine, and are in the form of pain and swelling at the site of the injection, pain in the body and a high temperature, but none of these symptoms poses a danger to the recipient of the vaccine.

While these side effects disappear or are greatly reduced with the inactivated Sinovac vaccine.

But in the end, there is no better vaccine than another, all vaccines are good and effective in protecting against corona and from deaths and severe disease suffering from Covid-19.

However, it must be emphasized that both vaccines are effective in reducing deaths and severe infection with the Coronavirus, and they are effective for all previous groups.

The previous data are indicative only. Choosing the type of vaccine is a matter determined by the health authorities in your country, and you can discuss it with your doctor.

 Corona vaccine must be received of whatever type

Professor Baliq stressed the importance of citizens receiving the Corona vaccine of whatever type, in order to form community immunity against the epidemic, because it has been clearly proven that anti-virus vaccines of various kinds help reduce deaths and the suffering of severe disease.

The professor added that all vaccines currently used are effective against the new mutated strain of Corona.

He said that the world is currently witnessing an increase in the number of epidemics due to new mutations of the virus, most notably those that appeared in England and spread to many countries, especially European ones.

He pointed out the importance of individual precautionary measures in facing the epidemic, and that it can be overcome globally by publishing vaccination campaigns.

He explained that the death rates due to the epidemic and critical cases have decreased significantly worldwide with the start of vaccination, and that it will be controlled as soon as possible with the vaccination of larger numbers.

Baliq indicated that the vaccines currently used have not been affected by the new mutation of Corona, and that they are still effective against that strain.

And he added, "If more than 60% of the population in a country is vaccinated, group immunity is formed, because another part of the population has been infected in a natural way, and therefore the virus does not pose a major problem or threat in that country."

Vaccine components (WHO)

Balik stated that the vaccine that is being applied in Turkey to this day is Koronavak, and that the Pfizer-Biontek vaccine has also arrived in the country.

He explained that Ankara University participated in the third phase trials of the Pfizer-Biontec and Koronavac vaccines, and that citizens should receive either of them according to what is available to him.

And it was shown that both vaccines are effective in reducing deaths and severe infection with the virus.

He added, "The data in Turkey show that severe injuries no longer appear among those over the age of sixty, and that most critical cases occur among those aged 40 to 60."

He discreetly advised citizens to receive the vaccination, whether it is Sinovac or Pfizer-Biontek.

What are the ingredients of vaccines?

The World Health Organization says that vaccines contain "fragments" of very small "pieces" of the organism causing the disease or on the initial scheme to form very small shells, and also contain other components to maintain the safety and efficacy of vaccines, and these last components are included in most vaccines, and have been used for decades In billions of vaccine doses.

Each component of the vaccine has a specific purpose, and it is subjected to testing in the manufacturing process, and all components are tested for safety.

The vaccine consists of:

  • Antigen: It generates an immune response, or contains the initial blueprint for the formation of the active component.

    The antigen may be a small part of the disease-causing organism such as protein or sugar, or the entire organism may be in its attenuated or inactivated form.

  • Preservatives, which prevent contamination of the vaccine after opening the vial that contains it if it is used to vaccinate more than one person, and some vaccines do not contain preservatives;

    Due to the fact that these vaccines are stored in single-dose vials and disposed of after the administration of a single dose.

  • Stabilizers, which prevent chemical reactions inside the vaccine and prevent the vaccine components from sticking to the vaccine bottle.


  • Surfactants, which maintain a good mixing of all pollen components, and prevent the elements present in the liquid form of the vaccine from precipitating and clumping them.

  • Residuals, which are very small quantities of various preparations used during the manufacture or production of vaccines, and do not form active ingredients in the completed vaccine, and these preparations differ according to the manufacturing process used, and may include egg proteins, yeast or antibiotics.

  • Diluent, which is a liquid used to dilute a vaccine, so that it reaches the correct concentration level prior to use.

    The most commonly used diluent is sterile water.

  • Adjuvants, found in some vaccines, improve the immune response to the vaccine, sometimes by keeping the vaccine at the injection site for a little longer, and sometimes by stimulating local immune cells.