Mechanism of stem cell therapy in children with dilated cardiomyopathy
Innovation Connection Japan
A research team at Okayama University Hospital in Japan, through the implementation of stem cell transplantation in pig models of dilated cardiomyopathy and pediatric dilated cardiomyopathy patients, found that the heart function that has fallen into heart failure can be restored.
Especially in the extracellular vesicles secreted by the transplanted cells, the microRNA named miR-146a-5p can directly exert an anti-inflammatory effect, thereby preventing the fibrosis of the damaged heart tissue and also helping to predict the therapeutic effect.
The study also confirmed that the six types of microRNAs detected in the pig model are all present in large amounts in extracellular vesicles derived from the patient's heart stem cells.
In particular, the expression of miR-146a-5p has a significant correlation with the recovery of heart function in transplant patients.
The research team experimentally introduced miR-146a-5p into human cardiomyocytes and found that it can inhibit the production of three important inflammatory cytokines and strongly inhibit cardiomyocyte death and tissue fibrosis, thus confirming the above clinical phenomenon .