How do you understand the medication time on the instructions?
Choosing the right time to take the medicine can not only effectively guarantee the therapeutic effect of the medicine, but also reduce the side effects of the medicine.
The interval between taking medicine is determined according to the kinetics of the metabolism of the medicine in the body. Only by taking the medicine at the time interval specified in the instructions can the medicine maintain a relatively stable therapeutic concentration in the human body.
If you want to achieve the best therapeutic effect, you should not shorten the time of taking the medicine or take the medicine irregularly, so as to avoid excessive drug concentration causing drug poisoning or too strong side effects, or too low concentration to achieve the expected therapeutic effect.
Common drug taking time in the drug insert:
1. Morning clothes: refers to 1 hour before eating breakfast after getting up in the morning, such as anti-tuberculosis drugs rifampicin and isoniazid in the morning, can produce good sterilization effect.
2. Fasting: Many people think that as long as you keep an empty stomach while taking the medicine, you can go to eat immediately after taking the medicine.
This is actually a wrong view.
It refers to taking the medicine 1 to 2 hours before a meal or about 2 hours after a meal, such as enteric-coated tablets, which are not easily disintegrated in the gastric juice and can only be absorbed in the intestine, so it is generally required to take the medicine on an empty stomach.
3. Before meals: 30 to 60 minutes before meals.
There is little food in the stomach before meals, which is conducive to the absorption of drugs. Generally, drugs that are not irritating or less irritating to the stomach or drugs that need to act on the stomach need to be taken before meals, such as gastric mucosal protective drugs and gastrointestinal motility drugs , Acid inhibitors, cephalosporins, antidiarrheal drugs, etc.
4. Meal: refers to the moment before or after a meal; the middle finger of the meal is taken with food, such as a glucosidase inhibitor (acarbose) competitively inhibits glycoside hydrolase in the small intestine to increase blood sugar after a meal Decrease, only taking the medicine while eating can produce a therapeutic effect.
5. After a meal: refers to 30 minutes to 1 hour after a meal.
6. Before going to bed: 15 to 30 minutes before going to bed.
7. When necessary: Take it immediately when there is pain or sudden condition.
8. Once a day: once a day in the morning or at night, and keep taking the medicine at the same time every day.
9. Twice a day: Generally, once a day for breakfast and dinner, the interval is about 12 hours.
10. Three times a day: Strictly speaking, three times a day refers to taking the medicine 24 hours a day and night in three time periods, that is, taking the medicine once every 8 hours.
However, in real life, in order to better comply with the patient, it is generally recommended that the patient determine the dosing interval in 3 segments outside of sleep.
It is generally recommended to take the medicine before breakfast, lunch and dinner or after meals.
However, some drugs, such as antibacterial drugs, antiepileptic drugs, and Parkinson's treatment drugs, will clearly specify the time of taking the drug, such as "take the drug every 8 hours", which should be strictly followed.
11. Multiple times a day: Try to split equally within 24 hours and coordinate with the work and rest time.
12. The glucocorticoid administration time is a daily dose between 7 am and 8 am.
Because of the diurnal changes in the secretion of glucocorticoids, the peak of its own secretion is at 7 to 8 in the morning. If you take exogenous corticosteroids at this time, the inhibitory effect of the hypothalamic-pituitary-adrenal axis will be minimized, and then reduced side effect.
At the same time, it is quite common to use Chinese and Western medicine in daily life, and whether to take it at intervals also needs to be considered.
The combined use of Chinese and Western medicines is likely to cause drug interactions. For example, when ebony and vitamin B12 are used together, it will reduce the bioavailability of vitamin B12.
Therefore, we usually need to have a certain time interval when we use Chinese and Western medicine in combination. Generally speaking, the interval should be more than half an hour.