On September 26 this year, the specific nucleic acid sequence of the variant gene submitted by Jiangxi Children's Hospital was published in the "GenBank database" of the National Center for Biotechnology Information, with the nucleic acid sequence number MN845955.
Photo courtesy of Jiangxi Children's Hospital
China News Service, Nanchang, October 15 (Xu Xiuyun, Liu Xin, Shu Jin, Wu Pengquan) Jiangxi Children’s Hospital announced on the 15th that the hospital recently discovered a new D allele genotype of the RH blood group system, and it has passed the U.S. National Expert review by the Biotechnology Information Center refreshed the global blood group database.
On September 26 this year, the specific nucleic acid sequence of the variant gene submitted by Jiangxi Children's Hospital was published in the "GenBank database" of the National Center for Biotechnology Information, with the nucleic acid sequence number MN845955.
In 2019, the Department of Blood Transfusion of Jiangxi Children's Hospital discovered a new D allele genotype of the human RH blood group system on the blood red blood cells of a 2-year-old child and his family.
After investigation, the above-mentioned children and their fathers, uncles, and grandmothers all have this RhD variant allele, showing family heredity.
According to the hospital, during routine serological examinations, the child’s RhD blood type test result was weakly positive (1+), which was far weaker than the ordinary RhD blood type positive result (4+), and it was easy to be mistaken as RhD negative.
The RhD gene of the patient was sequenced, and the results showed that there was a new (95C>A) point mutation in the nucleic acid sequence of exon 1, which had not been reported globally before.
According to the analysis of the family results of genetic testing, the characteristics of this gene are: when it exists alone (the other RhD gene is missing), the RhD antigen will be weakly expressed, and the RhD blood type will be weakly positive during inspection.
"In most cases, a person has two normal RhD genes, which is positive for the RhD blood group. Some people have one RhD gene missing, and one RhD gene has a mutation. Depending on the mutation, the expression of the RhD antigen is weak. The positive is weakened, or the expression of RhD antigen is not expressed as RhD negative." Zhou Genshui, director of the blood transfusion department of Jiangxi Children's Hospital, said that the discovery of new RH blood group genotypes not only refreshed the global blood group database, but also helped to ensure the safety of clinical blood transfusion.
Jiangxi Children's Hospital stated that the "GenBank database" contains all known nucleic acid sequences and protein sequences in the world, as well as their related literature and biological notes. "GenBank database" exchanges data with "European Molecular Biology Laboratory Database EMBL" and "Japan DNA Database DDBJ Database" every day to form an international nucleic acid sequence database, and freely disclose DNA sequences to the world. (Finish)