China News Service, August 28 (Chen Jing, Wang Yihui, Liu Fangqi) Genetic gastrointestinal tumor-causing genes may cause the offspring of patients to be at a long-term high risk of suffering from multiple tumors, which is called the carcinogenic curse of imprisoned families.
The Shanghai Anti-Cancer Association Genetic Gastrointestinal Tumor Special Committee (abbreviated as: Special Committee) was established on the 28th. It will strive to crack the transmission of genetic digestive tract tumors in the family, and give patients and family members precise and effective treatment and scientific prevention. And form industry consensus and standards to make diagnosis and treatment "rules to follow."
It is understood that the special committee consists of Professor Cai Sanjun from the Cancer Hospital of Fudan University as the honorary chairman, and hires Professor Mo Shanjing, Professor Lu Dalu, Professor Zhang Liying and other well-known experts as academic advisors. The special committee will gather the wisdom of experts here, form an expert consensus, and coordinate multi-center clinical randomized controlled studies.
Professor Xu Ye, director of the Department of Colorectal Surgery, Fudan University Cancer Hospital, who was newly elected as the chairman of the special committee, introduced that digestive tract cancers such as bowel cancer, gastric cancer, and pancreatic cancer are related to family genetics to a certain extent. In clinical practice, about 30% of patients with colorectal cancer are highly hereditary, and eventually 5% to 6% of patients will be diagnosed with hereditary colorectal cancer. In gastric cancer and pancreatic cancer, about 10% of patients present family clusters.
Professor Xu Ye said that hereditary gastrointestinal tumors have attracted the attention of the medical community. There are many multi-center clinical studies on genetic gastrointestinal tumors in China. "Because of China's vast territory, a major feature of genetic diseases is that different regions may have different characteristics. At the same time, relevant clinical diagnosis and treatment and research are relatively scattered, lacking industry consensus and diagnosis and treatment standards, and academic groups are in urgent need of cohesion, Hui Zhongzhi'cracked the'genetic curse' of this type of disease." Professor Xu Ye pointed out the current problems.
It is understood that the Department of Colorectal Surgery, Affiliated Tumor Hospital of Fudan University has long been committed to the clinical and scientific research of hereditary tumors, and has accumulated relevant data on more than 500 families with hereditary bowel cancer. In 2017, the hospital opened a colorectal cancer genetic consultation clinic. Many "invisible" patients or disease-causing gene carriers were screened by doctors, and effective "blocking" and intervention were obtained at the initial stage of the disease, and the risk of disease was greatly reduced.
Professor Xu Ye told reporters about a case. "Six years ago, a female patient with familial adenomatosis was hospitalized. During this period, I suggested that the son who was accompanying the patient undergo a colonoscopy. At first he resisted, thinking that he was only 20 years old and had no symptoms. Ill. After repeated persuasion, he completed the colonoscopy. The doctor found that his large intestine was already covered with hundreds of polyps of various sizes. Then I performed surgery on him, but fortunately all the polyps were not cancerous. He Up to now, I am glad that I listened to the doctor's advice." Professor Xu Ye was very pleased.
How to effectively identify hereditary tumors? Professor Xu Ye pointed out that such patients have three characteristics: the age of onset of patients is early, there are multiple primary lesions, and the appearance of rare and rare tumors.
According to reports, patients with hereditary colorectal cancer are often younger than 50 years old, and tumors may appear in different places at the same time. Patients and relatives may have rare or rare tumors such as small intestine cancer, renal pelvic cancer, and ureteral cancer. Xu Ye said that these may be the manifestations of hereditary colorectal cancer in other organ systems.
The expert said that as long as the diagnosis and treatment are timely, the survival prognosis of hereditary colorectal cancer is not bad. In some subtypes, the survival rate of patients is even better than that of sporadic colorectal cancer of the same clinical stage. According to him, the 5-year survival rate of Lynch syndrome patients who receive early intervention and comprehensive treatment can reach 97.6%.
"Genetic gastrointestinal tumors are often a mixed state of me and me. The disease has a wide range of diseases and many crossovers. It is very necessary for professional doctors to diagnose and treat, otherwise improper treatment methods are prone to appear." Xu Ye The professor emphasized.
Professor Cai Sanjun told reporters that the committee will formulate standardized clinical diagnosis and treatment manuals in the near future, map genetic mutations of gastrointestinal tumors in the Shanghai population and even the Chinese population, and establish a large database, and strive to improve Shanghai through multidisciplinary collaborative participation. The clinical diagnosis and treatment and family management level of hereditary gastrointestinal tumors in the city to form experiences and practices that can be replicated and promoted. (Finish)