BEIJING, July 9th (Chen Jing Xu Wei) Bone defects caused by trauma, tumor resection, and congenital diseases can lead to bone deformities and dysfunctions, which seriously affect patients' daily lives.

  Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine disclosed on the 9th that the team of professor Fan Xianqun of the Department of Ophthalmology of the hospital and the team of professor Yang Dapeng of Quanzhou Normal University developed a new type of bone repair nanomaterials derived from eggshells and developed biological activities Bionic stent, which provides new ideas for the repair and treatment of bone defects.

  The hospital revealed that the internationally renowned academic journal "Chemical Engineering Journal" published this research result online.

  It is reported that in recent years, the rapid development of tissue engineering has injected vitality into the field of bone defect repair research. Scientists have made a lot of efforts to synthesize bionic inorganic materials by imitating the natural inorganic components of bones. There are still complex synthesis processes and huge structural differences Many other issues need to be resolved urgently.

  Fan Xianqun said that in daily life, a lot of eggshell waste is generated every day. As a natural material whose main component is calcium carbonate, eggshell is rich in various trace elements, which can play an important role in promoting angiogenesis and osteogenesis. However, the expert admits that, prior to this, the application of eggshells in the field of bone regeneration was rarely carried out.

  The orbital bone repair research team led by Professor Fan Xianqun and the nanomaterials research and development team led by Professor Yang Dapeng proposed that eggshell particles may be used as a biological filler, modified and incorporated into related materials to crosslink to prepare bionic bone repair materials.

  The team used simple impregnation and calcination to synthesize related eggshell microcrystals and prepared a bionic scaffold. Experiments of repairing bone defects in rat skulls show that the new composite scaffold has a good effect of repairing bone defects. Researchers' analysis of the material's mechanism of promoting bone differentiation shows that the composite scaffold can achieve multiple ways to promote bone formation. (Finish)