China News Online, June 12 (Chen Jing, Wang Yihui, Zhu Yao) The reporter learned on the 12th that the latest multidisciplinary comprehensive diagnosis and treatment research results of Chinese medical experts confirmed that accurate PET/CT can effectively detect prostate cancer metastasis that traditional imaging examination failed to detect. The lesions, and break the conventional understanding of the medical community that "as long as the transfer can not be surgically treated", provides a more accurate imaging basis for the development of this part of the patient's treatment plan.
This means that in the future, doctors can formulate individualized treatment plans based on metastatic lesions found by accurate examinations to provide more effective and more accurate treatment plans for patients with advanced prostate cancer, thereby greatly improving the cure rate and survival period of prostate cancer.
The research results were published online in the "Clinical Cancer Research" official journal of the American Cancer Society. Photo courtesy of Fudan University Cancer Hospital
The research result of the collaboration between Professor Ye Dingwei, the leader of the Department of Urology, Fudan University Affiliated Tumor Hospital, and Director of Shanghai Urological Oncology Institute, and Professor Song Shaoli, Director of the Department of Nuclear Medicine, was published online in the official journal of the American Cancer Society, "Clinical Cancer Research."
Professor Ye Dingwei, who has been devoted to early screening of the prostate cancer community for many years, told reporters on the 12th that the proportion of early stage cancer patients in China as a whole is still quite low. He said: "The biggest difference between Chinese patients with prostate cancer and developed countries in Europe and the United States is that 30% of Chinese patients are already in the advanced stage at the time of initial diagnosis, while the patients in developed countries in Europe and the United States are mostly early."
Precise PET/CT makes up for the "blind area" of traditional image inspection Photo courtesy of Fudan University Cancer Hospital
It is reported that once the patient's disease has progressed to the middle and late stages at the time of initial diagnosis, it means that many patients have lost the opportunity for radical surgery, and these patients can often only control the progression of the disease through endocrine therapy. The expert told reporters that "patients who can receive radical surgery account for only one-third of the newly diagnosed patients." Professor Ye Dingwei said that almost all patients undergoing traditional endocrine therapy become resistant after 1 to 2 years Prostate cancer, the condition deteriorates rapidly.
In the past, the disease staging of patients with advanced disease mainly relied on traditional imaging examinations, but due to insufficient precision, small metastatic lesions were often missed, resulting in "non-metastatic" artifacts and delayed treatment. Professor Ye Dingwei and Professor Song Shaoli, director of the Department of Nuclear Medicine, jointly found that 73% of patients who were considered "unmetastatic" in traditional imaging examinations had actually developed lymph nodes or distant metastases.
The research team mapped the world's first oligometastasis distribution map of patients with castration resistance (endocrine therapy failure) prostate cancer, opening a window for such patients to explore new treatment methods. According to reports, among the 114 lesions detected, bone metastases account for approximately 52%.
Researchers have also changed the conventional wisdom that “surgery cannot be performed as long as metastasis” and found that in the early stage of castration resistance (endocrine therapy failure), about 51% of patients can undergo related surgery or radiotherapy. New research has benefited patients. Uncle Wang found two early metastatic lesions through precise imaging examination. Professor Ye Dingwei formulated for him on the basis of systemic treatment: a comprehensive treatment method of local robotic surgery plus precise radiotherapy of metastases, and finally the lesions reached complete after treatment ease.
At present, the 5-year survival rate of patients with prostate cancer at the Cancer Hospital of Fudan University is 82.6%, which is better than the domestic average of 69.2%. Professor Ye Dingwei said that under the close promotion of scientific research and clinical practice of the multi-disciplinary team, in the future, domestic patients with advanced prostate cancer will usher in more vitality. (Finish)