Zhong Nanshan team: restrictive pulmonary ventilation dysfunction in patients with severe pneumonia is relatively serious

(Fighting against New Coronary Pneumonia) Zhong Nanshan team: Patients with severe pneumonia have relatively severe restrictive pulmonary ventilation dysfunction

　　China News Agency, Guangzhou, May 21 (Cai Minjie, Jian Wenhua) The Guangzhou Institute of Respiratory Health said on the 21st that the team of Zhong Nanshan, a member of the Chinese Academy of Engineering, first reported the lung function characteristics of patients with new coronary pneumonia when they were discharged, and found that some patients have different degrees of lung function damage, and The damage is related to the severity of the illness during hospitalization. The research results were published online in the European Journal of Respiratory, an authoritative academic journal in the field of respiration.

　　It has been found that some patients with new coronary pneumonia still have chest imaging abnormalities of varying degrees, but the effect of new coronary pneumonia on patients' lung function has not been reported. Recently, the First Affiliated Hospital of Guangzhou Medical University / Guangzhou Institute of Respiratory Health Zhong Nanshan and Li Shiyue team and the Lei Chunliang team of the Eighth People ’s Hospital of Guangzhou jointly reported the lung function characteristics of patients with new coronary pneumonia during the rehabilitation period, and found that some patients have different degrees of discharge Lung function damage is mainly manifested in lung diffusion dysfunction, followed by restrictive ventilation dysfunction, and the damage is related to the severity of the disease during hospitalization.

　　The above study included 110 patients with new coronary pneumonia who underwent lung function tests at discharge. The study found 51 cases (47.2%) with abnormal lung diffusion function (DLCO), 27 cases (25.0%) with abnormal total lung volume (TLC), and 15 cases (13.6%) with abnormal first-second forced breathing volume (FEV1). There were 10 cases (9.1%) with abnormal vital capacity (FVC), 5 cases (4.5%) with abnormal one-second rate (FEV1 / FVC), and 8 cases (7.3%) with abnormal small airway function.

　　According to the study, there are significant differences in the proportion of abnormal lung diffusion between different subgroups of severity, 30.4% for mild, 42.4% for normal, and 84.2% for severe (p <0.05); as the severity of the disease increases, the lung diffusion The impaired function is more obvious. The TLC share of severe patients is much lower than that of light or ordinary patients, which indicates that patients with severe pneumonia have relatively more severe pulmonary dysfunction.

　　The research results were published online on May 7 in the authoritative academic journal of the respiratory field "European Respiratory Journal". The first authors were Mo Xiaoneng, Jian Wenhua and Su Zhuquan, and the corresponding authors were Li Shiyue, Chen Ruchong and Zhong Nanshan. For the first time, this study summarizes the lung function characteristics of patients discharged with new coronary pneumonia, suggesting that lung function tests should be included in the follow-up of patients with new coronary pneumonia, especially for patients with severe disease, and lung rehabilitation can also be used as a follow-up intervention. (Finish)