Expert: Lupus nephritis is more common in women of childbearing age with multidisciplinary collaboration to help standardize diagnosis and treatment
China News Service, Beijing, May 10 (Reporter Li Yanan) May 10 this year is "World Lupus Day" and "Mother's Day." Experts pointed out that lupus nephritis is a high incidence of autoimmune diseases in women, and its diverse clinical manifestations bring many challenges to the diagnosis and treatment of the disease. At present, the importance of standardized treatment should be emphasized, from diagnosis and treatment to long-term management. Multiple departments are required to participate.
Academician Liu Zhihong of the National Kidney Disease Clinical Medical Research Center (Eastern Theater General Hospital) introduced that systemic lupus erythematosus (systemic lupus erythematosus (SLE)) is the most common systemic autoimmune disease in China. Recurrence and damage to organ function are the main clinical features. The prevalence of SLE in China currently ranks second in the world. The kidney is the most commonly involved organ in SLE, and 40% -60% of SLE patients have lupusnephritis (LN) at the beginning of the disease. 10% -20% of LN patients will progress to end-stage renal disease (ESRD) in 5-10 years.
According to reports, patients with lupus nephritis are mainly female patients of childbearing age. The traditional treatment plan provides effective treatment, but often damages the ovaries of the patients, causing premature ovarian failure of this group of women. Once premature ovarian failure occurs, in addition to affecting fertility, it will also lead to premature decline in female characteristics, as well as adverse effects such as reduced bone density, cardiovascular disease, psychological problems, and cognitive impairment (such as increasing the risk of dementia).
Academician Liu Zhihong pointed out: "We not only treat diseases, but also take care of the social roles and mental health of patients. Many patients with lupus nephritis are in the stage of life transformation of love, marriage, and childbearing. The protection of lupus nephritis is not only effective, but also more humane. With the improvement of standardized diagnosis and treatment, the long-term survival time of patients with lupus nephritis has been significantly extended. In addition, the application of innovative immunosuppressants can also be more Less affect the patient's ovarian reserve function. Therefore, we must pay attention to protect the ovarian function of these patients and improve their long-term quality of life. Paying attention to the ovarian reserve function not only regulates the diagnosis and treatment of lupus nephritis, but also protects the patient's family happiness. "
Lupus nephritis is a systemic disease that requires multiple departments to participate from diagnosis and treatment to long-term management. Professor Zeng Xiaofeng, director of the Department of Rheumatology and Immunology of Peking Union Medical College Hospital emphasized: "On the one hand, the participation of multi-disciplinary doctors such as rheumatology, nephrology, reproductive medicine, and pathology will help more standardized diagnosis and treatment and help patients improve the efficacy; on the other hand, China Since last year, the clinical guidelines for systemic lupus erythematosus and lupus nephritis have been successively updated and published. These guidelines combine Chinese disease characteristics and clinical data to better guide clinicians' diagnosis and treatment. We need to build a multidisciplinary diagnosis and treatment platform as soon as possible to promote Multidisciplinary exchanges and cooperation promote the development of standardized diagnosis and treatment of lupus nephritis. "
In order to promote the standardized diagnosis and treatment of lupus nephritis in China, on May 10, Beijing Bethune Public Welfare Foundation initiated, Roche Pharmaceuticals China supported, rheumatology department and nephrologists in more than 50 hospitals jointly launched "Dieyou Shiwang-Bethune · Lupus Nephritis "Standardized diagnosis and treatment plan" to jointly promote interdisciplinary linkage diagnosis and treatment.
The director of Beijing Bethune Public Welfare Foundation, Li Shen, said: "Most patients with lupus nephritis are women of childbearing age. They are in a period of love, marriage, fertility and hard work. The treatment plan needs to take into account the efficacy, fertility and even psychological needs, which requires Participation of multidisciplinary experts. 'Dieyou Shiwang-Bethune · Lupus Nephritis Standardized Diagnosis and Treatment Plan' is the first to be launched in more than 50 hospitals across the country. It will promote the development of interdisciplinary linkage diagnosis and treatment and continue to carry out clinical doctors' standardized diagnosis and treatment training activities. " (Finish)