Exposure to some stresses at an early age may lead to a longer life, according to research results conducted on one of the types of roundworms, which are slender grace.
In a report published by "Genetic Engineering and Biotechnology" on a recent study by scientists from the University of Michigan, it showed that the oxidative stress we are experiencing early in life increases our ability to resist stress in future periods of life, according to Daphne Pazopoulou, who has Doctorate and first researcher in the published study in the Nature journal.
Genetics, environment and other factors
"Given the strong relationship between stress, aging and age-related diseases, early events in life can also affect our readiness for age-related diseases, such as dementia and Alzheimer's," the website quoted Ursula Jacob, a study reporter and professor of molecular biology, as saying.
According to the researchers, "Estimates indicate that the genetic effects on the differences observed in human lifespan are only between 10 and 25%." The environment is another factor, yet the puzzle is not fully resolved.
The site stated that other factors may be evident in the case of agile buddies, as these round worms that do not live for a long time are a popular system of research in aging, partly because each bisexual worm produces hundreds of genetically identical offspring.
However, when genetically identical worms are studied under the same environmental conditions, their life span can vary by more than fifty times.
"If the shelf life is determined solely from genes and the environment, we can expect all genetically identical worms to die around the same time, but this is not what happens at all" where "some worms live only three days while some remain The other one is moving smoothly after twenty days. "
|Genetically and environmentally identical worms of worms may vary by more than fifty times their age (Wikimedia Commons)|
Reactive oxygen types
The site pointed out that there are so-called "reactive oxygen types", which are oxidants produced by every living organism that breathes air, and are closely related to aging, as the oxidative damage it causes is similar to the damage that many anti-aging creams claim to fight.
He added that oxidative stress occurs when cells produce more oxidants and free radicals than they can handle, and although oxidative stress is part of the aging process, it can also arise from stress-causing conditions such as exercise and restricting caloric intake.
In this context, researchers at the University of Michigan decided to study whether temporary changes in reactive oxygen species affect the shelf life of Worms.
Oxidative stress and histone
The team concluded that the individual worms worms differed significantly in terms of the amount of reactive oxygen that they produced, as those worms - which produced more reactive oxygen species during their development - may have lived perhaps longer than those that produced less reactive oxygen species during The early period of her life.
|Histone protein levels in worms vary according to oxidative stress factors 2 (Wikipedia)|
Interestingly, when researchers demonstrated the group of young worms to reactive oxygen species during the growth period, they found that the average life of the entire group increased. The team also conducted studies to determine what mechanisms could contribute to increasing the life span of these worms.
To do this, researcher Bazobulu classified thousands of slender agile larvae according to the levels of oxidative stress they showed during development.
By separating the worms that produce large amounts of reactive oxygen from those that produce small quantities of them, she revealed that the main difference between the two groups was the variation in the rate of alkaline "histone" whose activity was found to be affected by oxidative stress factors.
And a question says: How do you communicate then these changes or how does the end of life affect the life span? What is certain is that the histone protein rate is also affected by the oxidative stress that occurs also in mammalian cells.
Finally, researchers are looking to see the most significant changes stimulated by these early life events. Understanding this may allow scientists to develop initiatives that will play a role in extending shelf life.