Queen Boudicca led an uprising against the Romans in 60/61 AD. Isabella of Castile laid the foundation for the Spanish empire during her 30-year rule.
Malinche was the first half-indigenous, half-Spanish “mestizo” Queen Cixi rose from concubine to become the most powerful woman in the Chinese Qing Dynasty. Meir Meir signed the Golda Meir Declaration of Independence with her husband, Israel's Prime Minister in 1969.