The game at the San Siro Stadium ended 3-0 in favor of Simone Inzaghi's team.
The goals were scored by Stephan de Vrey (21st minute), Nicolo Barella (44th), Joaquin Correa (73rd).
Inter are fifth in the standings with 24 points.
Sampdoria (six) is in 18th position.
Earlier it was reported that thanks to a goal and two assists by Khvichi Kvaratskhelia, Napoli defeated Sassuolo.