The match in Nicosia ended with a score of 3:2 in favor of the team of Erik ten Hag.
As part of Manchester United, goals were scored by Marcus Rashford (53rd, 84th minutes), Anthony Martial (63rd).
Karim Ansarifard (34th), Nicolas Panayotiou (85th) scored against Omonia.
Earlier, Borussia won a crushing victory over Sevilla in the Champions League match.