The meeting lasted 2 hours 30 minutes and ended with a score of 7:6 (7:5), 4:6, 6:4, 6:1 in favor of the second racket of the world.
Daniil fired 13 times, made 39 winners and made 28 unforced errors.
In addition, he significantly outperformed his opponent in the game on the reception (34% of points won against 19%).
Tsitsipas has five aces, 35 actively won points and made 32 unforced errors.
Thus, Medvedev reached the final of the Australian Open for the second time in a row.
Last year, he lost to Serb Novak Djokovic.
The 25-year-old Russian will face 20-time Grand Slam champion Spaniard Rafael Nadal in a decisive match against Italian Matteo Berrettini.
Earlier it was reported that Tsitsipas received a remark for coaching during the match with Medvedev.