31-year-old Brignone took home the victory in Zauchensee.
The podium was completed by Ariane Rädler, Austria, third and Corinne Suter, Switzerland, second.
It was Brignone's second World Cup victory of the season and the 18th overall in his career.
Countryman Sofia Goggia came to the start despite yesterday's nasty crash - but finished in nineteenth place.
- I think Brignone and Goggia trigger each other.
But when Brignone goes like this, she is not unbeatable but very good, says SVT Sports expert Pernilla Wiberg
Sweden had two participating skiers in the form of Estelle Alphand, 26, and Lisa Hörnblad, 25. But it was not a successful day for either of them.
Hörnblad went out and Estelle Alphand had the second worst time of those who finished, 3.96 after winning Brignone.