The 26-year-old striker has been suffering from a stubborn cruciate ligament injury since the beginning of 2020 and made a comeback in October against Häcken in the Champions League.
In the league match at home against PSG, the first goals also came.
Hegerberg was substituted in the 74th minute in a 4-0 lead.
Eight minutes later, she had written in the goal record twice.
Just before Hegerberg's double hits, Amanda Ilestedt scored a consolation goal for her PSG.
The French summit has otherwise been preceded by a major scandal in PSG.
Midfielder Kheira Hamraoui was recently attacked when two masked men pulled her out of a car and beat her.
Teammate Aminata Diallo was arrested in connection with the act, but has since been released after questioning.
- I'm still floored by this incident.
Not even among the gentlemen have we seen anything like it.
It is of course negative for women's football, Lyons coach, Sonia Bompastor, said about the incident.
Lyon top the table with eight wins in as many matches.
PSG, on the other hand, suffered their first loss in the league after seven straight wins, and are second.