The German team's Champions League journey began in the qualifiers where they comfortably beat FC Rosengård with a total of 6-3.
Then they got a dream start in the group game through a 5-0 victory at home against Norwegian Köge.
After that, it has been heavier.
Most recently, it was 0-4 away against Jonas Eidevall's Arsenal and today came the next heavy loss.
Spanish giants Barcelona took the lead after just five minutes - Lieke Martens served Jennifer Hermoso who had to break the deadlock.
14 minutes later it was time again.
"Barca" got a free kick a few meters outside the penalty area and superstar Alexia Putellas stepped forward.
The Spanish midfield giant snorted deliciously 2-0 behind Martina Tufekovic in the Hoffenheim goal.
More would come.
Putellas stepped forward and put 3-0 in the 33rd minute and in the second half she assisted Marta Torrejón to 4-0.
A return meeting between the teams awaits on 17 November.