The meeting, which took place on the central court of the Palais des Sports "Bercy" in the capital of France, ended with a score of 4: 6, 6: 3, 6: 3 in favor of the first racket of the world.
The game lasted 2 hours and 14 minutes.
The last time the match between Djokovic and Medvedev took place in the final of the US Open - 2021, where the Russian won.
The score on personal meetings was 6: 4 in favor of the Serbian tennis player.
The prize fund of the tournament is about € 3 million.
The 25-year-old Muscovite beat Alexander Zverev from Germany in the final of the 2020 tournament (5: 7, 6: 4, 6: 1).
Earlier, Medvedev shared his expectations from the Masters final with Djokovic.