"I want to thank all of you fans, doubters, critics, all of you - you have pushed me to higher and higher heights throughout my career and I am extremely grateful for that," Lloyd told the audience at the St. Paul Arena as she made her 316th and last international for the United States.
Lloyd's Gotham reached the quarterfinals of the NWSL playoffs - but there the journey stopped.
It was a 0-1 loss to Chicago after a goal by Mallory Pugh in the 61st minute and the longtime player's career thus ends.
The 39-year-old announced in August that she would put her shoes on the shelf after the season.
She had to end her national team career with an Olympic bronze this summer.