As part of the "townspeople" Ferran Torres scored a double (12th and 84th minutes).
Ilkay Gundogan (7th), Gabriel Jesus (43rd) and Rodrigo Hernandez (53rd) also scored one goal each.
The Gunners spent most of the match in the minority.
In the 35th minute of the game, Granit Jaka received a red card.
City with six points occupies the first line in the standings.
Arsenal suffered their third defeat in a row from the start of the Premier League.
Previously, former UFC two-weight champion Conor McGregor commented on the transfer of Portuguese footballer Cristiano Ronaldo to English Manchester United.