"After careful consideration and advice from my doctors, I have decided to withdraw from the US Open.
I will let my body heal completely ", she writes on Instagram.
Serena Williams has not played since the beginning of June when she injured herself in her first match at Wimbledon.
She has won the US Open six times, most recently in 2014. Her main merit this season was a semi-final place in the Australian Open.
Men's stars Rafael Nadal and Roger Federer have also been forced to cancel due to injury.
MORE TENNIS: Here, Daniil Medvedev crashes into the TV camera
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Here Daniil Medvedev crashes into the TV camera.
Photo: ATP Media