The meeting, which took place in Lyon at the Stade de Lumière, ended with a score of 3: 2 in favor of the guests.
The victory "Lille" brought goals from Jonathan David and Burak Yilmaz, who scored a double.
For Lyon he scored against Silam Slimani.
Own goal in the passive of the guest defender Jose Fonte.
Lille scored 73 points and returned to first place in the Ligue 1 standings, ahead of Paris Saint-Germain (72) and Monaco (71).
Lyon finished fourth with 67 points.
Earlier it was reported that Monaco with Golovin defeated Angers in Ligue 1.