Five skiers left with 13 km left of the 259 kilometer long race which is part of the so-called Monuments.
The race is one of the world's oldest and the first edition was decided as early as 1892.
In the last meters, Pogacar passed Julian Alaphilippe, reigning world champion and winner of the Walloon Arrow on Wednesday, and won by a couple of decimeters.
Tactically asked
- At the sprint, I knew that Alaphilippe would take a longer road and I chose to lie behind him.
I could come with speed and had a good wind.
It's unbelievable and I'm living my cycling dream, says Pogacar.
The big goal of the season is to defend the title in the Tour de France this summer.
- Now I will rest a bit and take time with the family and then I will start training and preparing for the Tour de France, says the 22-year-old.
Dutchwoman Demi Vollering won the women's class who drove 141 km.