At Estadio Nuevo Los Cármenes, Manchester United won 2-0 in the first quarter-final meeting with Granada.
And it was the Swedish midfield star Victor Lindelöf who was behind the away goal that gives United the advantage before the return.
Half an hour into the match, David De Gea took a short kick to Lindelöf, who was able to walk up the pitch without threat.
And was then given the opportunity to find the moment to hit a long ball.
And the deep lead pass of about 60 meters was perfect for Marcus Rashford who was responsible for an excellent takedown and pushed in 1-0.
"Sensational ball by Lindelöf", writes the local newspaper Manchester Evening News which gave Lindelöf the rating eight out of ten at half time.
First since 1965
Goal scorer Rashford is the first English player to score eight goals for Manchester United in European games (group and final) since Bobby Charlton in 1965.
Europa League debutant Granada, who knocked out Malmö FF in the playoffs, created several dangers but received no dividend in the form of goals.
Instead, the visitors extended in the final minutes, Yan Brice lowered Bruno Fernandes in the penalty area.
Chance from the penalty spot, Fernandes took care of the penalty himself and put it even though Rui Silva was on the ball with the glove.
2-0 to Manchester United, and the return will be decided next Thursday, April 15.
There, the Premier League runner-up will have to do without left-back Luke Shaw, team captain Harry Maguire and midfielder Scott McTominay due to suspension.