The only goal of the match came in the 20th minute.
Jonathan Ikoné unleashed a swerving effort from the right that the visitors' keeper did well to tip wide.
Jonathan David received the ball with his right foot and then sent in 1-0 via a PSG player.
PSG then chased a draw - without success.
It was a loss at home for the French big club
For Neymar, the match ended in red ..
PSG second in the league
He received a yellow card for unsportsmanlike conduct at the beginning of the second half when he became annoyed with an opponent.
At the end of the match, the brass pulled on his second yellow card when he pushed away a player to take the ball and start the game.
With the win, Lille tops the French top league. PSG is three points behind.