The heavyweights met for the first time in January 2018 at UFC 220 in Boston.
That time, Miocic won on points after five rounds.
The American then managed to avoid the onslaught from Ngannou in the first round, picking him down on the ground and exhausting him considerably.
From November 2018 onwards, the Cameroonian lined up four straight victories by knockout where all four matches together lasted for two minutes and 42 seconds.
Stipe Miocic has defended the heavyweight belt in the UFC more times than anyone else.
With the victory, Francis Ngannou becomes the third UFC champion with an African background.
Israel Adesanya and Kamaru Usman, both born in Nigeria, are already champions in middleweight and welterweight respectively.
The text is updated.
ARCHIVE: Khamzat Chimaev - UFC Swede who makes comet career (October 24, 2020)
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Khamzat Chimaev - UFC Swede making comet career Photo: SVT