56 minutes into the Serie A summit, Zlatan Ibrahimovic was replaced by Rafael Leao at the Stadio Olimpico in the Italian capital.
This after the Swedish striker already in the first half took the lead and stretched the groin.
- It was a muscle problem.
We are at a crucial stage of the season.
We hope it is not serious, because we need to have everyone available, says Milan coach Stefano Pioli.
During the initial 45, Ibrahimovic was also given many opportunities to score his 15th league goal of the season, but he did not manage them.
At one point he shot at a center-back who substituted on the goal line when the goalkeeper was out of position, and at another he ended up carelessly offside in a two-on-one position in the penalty area.
Rebic decided
Despite the Swede's missed opportunities, Milan scored two goals.
First, Franck Kessie, who gained penalty with Ibrahimovic remaining on the pitch, opened the scoring from the penalty spot after Davide Calabria was sent off.
Jordan Veretout equalized for Roma.
But two minutes after Ibrahimovic was replaced, Ante Rebic took the ball, turned away defenders and scored the decisive 2-1 goal with the left.
Milan are still second in Serie A, four points up to city rivals and league leaders Inter.