The match, which took place at the Bay Arena stadium in Leverkusen, ended with a score of 2: 1 in favor of the hosts.
Moussa Diaby and Florian Wirtz scored for Bayer.
Julian Brandt scored among the guests.
Bayer is second in the Bundesliga standings with 32 points.
Borussia has 29 points and the fourth line.
Earlier, Bayern beat Freiburg in a Bundesliga match.