Georgios Giakoumakis single-handedly helped VVV-Venlo to win in the relegation duel with ADO.
The Greek striker scored no less than four times in The Hague against the direct competitor: 1-4.
Sparta Rotterdam gave trainer Sjors Ultee his first defeat since his appointment as head coach of Fortuna Sittard: 0-1.
Giakoumakis was already twice accurate on Sunday in the relegation duel with Willem II (2-1).
With sixteen goals, the Greek, who was taken over by the Limburgers from AEK Athens this summer, is well in the lead on the top scorers list of the Eredivisie.
The 26-year-old Greek opened the score in The Hague in the sixth minute.
After a foul by Shaquille Pinas on Zinedine Machach, he used the penalty kick awarded.
After an hour of play, Giakoumakis doubled the score with a header from the inside of the post.
After Samy Bourard had brought the tension back in the 65th minute with the connection goal for ADO, the striker completed his hat-trick thanks to a grabbed keeper Luuk Koopmans.
From his second penalty, he also made it 1-4 just before time.
Shortly afterwards, he was rewarded in the empty stadium with a 'public change.'
Fortuna suffers first defeat under Ultee
For Fortuna Sittard the magnificent series under Ultee came to an end.
Since the 33-year-old trainer took over from the dismissed Kevin Hofland, thirteen points were taken from five games, but Sparta turned out to be 0-1 too strong on Wednesday.
Lennart Thy signed for the only goal of the match after an hour of play.
The German striker took advantage of a good pass from Mario Engels and then kept cool eye to eye with goalkeeper Yanick van Osch.
Lisandro Semedo came close to the equalizer.
A bet from the Fortuna attacker was removed just before the goal line.