His time on the 456-kilometer special stage was 5 hours 26 minutes 39 seconds.
This is the first success of the reigning Dakar champion in 2021.
The second place at the stage was taken by Belarusian Aleksey Vishnevsky in a MAZ truck.
He lagged behind Karginov by 2 minutes 42 seconds.
The third line in the final protocol was taken by another representative of KamAZ-master Dmitry Sotnikov (lag 3:41).
Earlier it was reported that Sotnikov's crew won the fourth stage of the Dakar.