The meeting, which took place at the Old Trafford stadium in Manchester, ended in a 6: 2 win for the hosts.
Doubles were scored by Scott McTominay and Bruno Fernandes, Daniel James and Victor Lindelof also scored.
The guests have goals on account of Liam Cooper and Stuart Dallas.
Manchester United are in third place in the standings with 26 points.
Leeds are in 14th position with 17 points.
Earlier it was reported that Manchester United footballer McTominay became the first Premier League player to score a double in the first three minutes of the match.