The meeting, which took place in Krasnodar, ended with a score of 2: 1 in favor of the guests.
Sevilla scored first.
Already in the fourth minute, Ivan Rakitich scored.
Krasnodar responded with a goal from Wanderson in the 56th minute.
The victory for the Spanish team was brought by the goal of Munir El Haddadi, who scored in the fifth minute stoppage by the second half.
In the next round, Krasnodar will host the French Rennes at home, while Sevilla will play against Chelsea London at home.
Earlier Marko Nikolic expressed his confidence that Lokomotiv is ready for the match with Atlético in the Champions League.