The meeting, which took place at the Roason Park stadium in Rennes, ended with a score of 1: 1.
Rennes scored first.
In the 56th minute, the penalty was converted by Seru Girassi.
Krasnodar responded with a goal from Christian Ramirez, who distinguished himself in the 59th minute with a pass from Tonny de Villena.
In the second round, Krasnodar will play host to London's Chelsea, while Rennes will play away against Spanish Sevilla.
Earlier it was reported that Zenit in St. Petersburg lost to Brugge in the Champions League match.