The duel, which took place in Las Vegas, lasted all 12 rounds.
The judges gave the victory to Lopez - 116: 112, 119: 109 and 117: 111.
Thus, Lopez became the undisputed world lightweight champion, having won titles belonging to the Ukrainian.
For the 32-year-old Ukrainian, this is only the second career defeat with 14 wins.
Lopez won 15 victories, and did not suffer a single defeat.
Earlier it was reported that the WBC did not receive requests to authorize the second fight between Povetkin and White.