The meeting lasted 1 hour 53 minutes and ended with a score of 1: 6, 6: 3, 6: 3 in favor of the 22-year-old Japanese tennis player.
For Osaka, this is his second career win at the US Open and his third Grand Slam singles title.
She won the US Open in 2018 and the Australian Open in 2019.
Azarenka, 31, has won two singles Grand Slam tournaments, winning the Australian Open in 2012 and 2013.
Earlier it was reported that Andrei Chesnokov named the favorite in the US Open men's final.