The meeting at Endfield ended 2-0 in favor of the home team.
The victory for Liverpool was brought by the goals of Mohamed Salah and Sadio Mane, who scored in the fourth and 64th minute of the match.
Liverpool with 58 points and a game in reserve after 20 matches leads the Premier League standings, 13 points ahead of the second Leicester City. Sheffield, with 29 points, remained eighth.
Earlier it was reported that the defender of the London Arsenal dropped out for a long period due to a knee injury.