Ajax starts with Perr Schuurs and Lisandro Martínez in the back of the Champions League match against Lille OSC. Noussair Mazraoui starts at Stade Pierre-Mauroy in midfield.
Schuurs and Martínez are the substitutes for Joël Veltman and Daley Blind, who are suspended after their red cards in the away match against Chelsea. Trainer Erik ten Hag could have opted for Edson Álvarez in the central back, but the Mexican starts on the bench.
Nicolás Tagliafico starts as left back as expected, while Ten Hag opts for Sergino Dest in the back right.
Mazraoui, who also regularly plays right back, moves on to midfield. The Moroccan international was a doubt for the Lille duel, after he was injured against Heracles Almelo on Saturday. Donny van de Beek and Hakim Ziyech complete the Ajax middle line.
Zakaria Labyad and Quincy Promes start on the wings and Dusan Tadic is on the point.
The match between Lille and Ajax starts on Wednesday at 9 p.m. in Stade Pierre-Mauroy and is led by referee Felix Brych. The other match in group H is between Valencia and Chelsea and that game has already started at 6.55 p.m. The resting position in Mestalla is 1-1.
Lille OSC setup: Maignan; Celik, Tiago Djalo, Gabriel, Mandava; André, Soumaré, Yazici; Icon Osimhen, Bamba.
Ajax setup: Onana; Dest, Schuurs, Martinez, Tagliafico; Mazraoui, Ziyech, Van de Beek; Promes, Tadic, Labyad.