The representative of the Netherlands finished in 1 minute 14.758 seconds.
The second was the Monegasque Charles Lecler from Ferrari with a lag of 0.266 seconds. The top three were closed by his teammate German Sebastian Vettel (+0.412).
Russian racer Toro Rosso Daniil Kvyat took ninth place.
Leclair had previously won third practice at the Mexican Grand Prix.