The meeting, which took place at the BayArena stadium in Leverkusen, ended 2-1 in favor of Lokomotiv.
As part of the "railroad" scored Grzegorz Krykhovyak and Dmitry Barinov. Bayer’s only ball was scored by Lokomotiv defender Benedikt Höwedes, who cut the ball into his own net.
Earlier, Tottenham Hotspur tied with Olympiacos in the Champions League, missing the two-goal lead.