After a spate of changes in Serie A coaches this summer, more than one team in the competition is looking to break Juventus' monopoly at the new season, which starts on Saturday.
Juventus won the title in the last eight seasons in a row, setting a record not only in the domestic league but also in the major leagues in the old continent.
Coach Maurizio Sarri's side are looking to win the title for the ninth season in a row, but this season they will face a greater desire from several clubs to end their dominance.
The "Old Lady" will start the campaign to defend their title on Saturday at Parma, where the game represents a good and strong preparation for the champion before hosting Napoli in the second round, where this game represents a classic summit between the two teams.
As Parma's match looks like a difficult task, veteran goalkeeper Gianluigi Buffon warned his team-mates not to consider it a definitive showdown.
Juventus will miss Serie A's seat as they continue to suffer from pneumonia, which will also prevent him from attending the second match against Napoli, the club announced on Wednesday.
Bologna coach Serena Sinisa Mihajlovic is also suffering from a more serious illness, as leukemia treatment began in mid-July.
Napoli start their season with a tough encounter away to Fiorentina.
Napoli finished second last season, their third runner-up in the last four seasons.
Fiorentina are looking for strong support from new veteran Frenchman Franck Ribery, who joined him this week after a long and busy career with Bayern.
Ribery has won nine Bundesliga titles with Bayern, including one under Napoli coach Carlo Ancelotti.
Roma face Genoa, and Lazio visit Sampdoria in their seven matches.
Milan also visit Udinese, host Torino Sassuolo, Spall meet Atalanta, and Cagliari against second division Brescia.
Inter Milan host Lecce at the end of Monday's matches.
Many believe that Inter will be the strongest rival of Juventus, where he signed "Nerazzurri" last May with the famous coach Antonio Conte.
Conte was born and started his football career in Lecce before playing for Juventus midfield for a long time.