One person was killed in a pile-up on the A65 near Berkel-Enschot (North Brabant) on Thursday afternoon.
Four people were also injured.
The road near Tilburg will be closed until 10 p.m., Rijkswaterstaat reports.
The accident happened around 2 p.m.
Three cars, a truck and a van collided with each other, a police spokesman said.
The identity of the fatal victim is not yet known.
Of the other four victims, one was taken to hospital with minor injuries, the three others were treated on site by ambulance personnel.
Traffic is being diverted.
Police are still investigating the cause of the accident.Keywords: