Bayer Leverkusen will play Azerbaijani club Qarabag Agdam again. Jürgen Klopp and Liverpool FC meet the reigning Czech champions Sparta Prague.
SC Freiburg is also playing against an old friend, West Ham United from England. The round of 16 first legs will take place on March 7th, the second legs a week later on March 14th. Only Sporting Lisbon's game had to be brought forward to March 5th because Benfica, a second team from Lisbon, progressed.