The first comprehensive study on the effects of extrapulmonary organs released
New coronary pneumonia can cause multiple organ damage in patients
Science and Technology Daily, Beijing, July 12 (Reporter Liu Xia) American scientists and clinicians wrote in the "Nature Medicine" magazine published on the 10th that they have completed the first comprehensive study of the impact of new coronary pneumonia on extrapulmonary organs, the latest The results show that the new coronary pneumonia may cause damage to the patient's heart and kidneys. The study is expected to provide clinical guidance for doctors.
According to the physicist organization network recently, Akati Gupta of Columbia University said: "Our review research shows that doctors need to treat new coronary pneumonia as a multi-system disease. There have been many reports of thrombosis in patients with new coronary pneumonia. Disease news, our research shows that some patients have kidney, heart and brain damage, these results are very important."
Harvard Medical School's Catic Saiga said: "In the first few weeks of the new coronavirus pandemic, we found many thrombotic complications, which exceeded our expectations." They believe that these thrombotic complications may be the source As the virus attacks the blood vessel cells: When the virus attacks the blood vessel cells, inflammation increases and blood begins to form clots of varying sizes. These blood clots can spread throughout the body and destroy organs.
To combat coagulation and its destructive effects, doctors at Columbia University are conducting a randomized clinical trial to study the optimal dose and timing of taking anticoagulant drugs in patients with severe new pneumonia. Inflammation can also excessively stimulate the immune system. Therefore, researchers are also conducting randomized clinical trials that target thrombus inflammation and specific components of the immune system, such as interleukin-6 signal transduction.
Blood clots can cause heart disease, but viruses can attack the heart in other ways. Gupta said: "The mechanism of heart damage is currently unclear because the probability of the virus being isolated from heart tissue in autopsy cases is not high."
Another surprising finding is that a high percentage of patients with new coronary pneumonia suffer from acute kidney injury. The new coronavirus enters human cells through the ACE2 receptor. The concentration of ACE2 receptor in the kidneys of these critically ill patients is very high, which may be the cause of kidney damage. Scientists currently lack data on long-term kidney damage.
In addition, the new study also found that about one-third of patients with new coronary pneumonia may have neurological symptoms, including headaches, dizziness, fatigue and loss of smell.
The researchers believe that follow-up research on the complications caused by new coronary pneumonia is essential.