Luleå looked to be headed for their first loss of the season at home when Djurgården took the lead 3-2 with just over four minutes left to play.
But Lisa Johansson equalized in the final minutes when she steered the puck into the roof of the net and after a scoreless overtime there were penalties.
There, Petra Nieminen became a hero when she scored the winner and settled the summit.
It was her second goal of the match after she had previously made it 1–1 on the power play in the second period.
Thus, Luleå won its fourth straight victory against Djurgården and second straight with the result 4–3.
The win means that Luleå leads the series with nine points to the credit of runner-up Brynäs, while Djurgården remains in third place.